According to the WHO, standard antiretroviral therapy (ART) consists of the combination of antiretroviral (ARV) drugs to maximally suppress the HIV virus and stop the progression of HIV disease. ART also prevents onward transmission of HIV. Huge reductions have been seen in rates of death and infections when use is made of a potent ARV regimen, particularly in early stages of the disease. WHO recommends ART for all people with HIV as soon as possible after diagnosis without any restrictions of CD4 counts

MARPI started providing ART services to KP/PPs in 2013 and have now a cummulative of more than 2700 KP/PP patients ever enrolled on MARPI where 1800 are FSW, 250 are MSM, 17 IDUs, 10 TGs and others in the priority populations. Key populations—which include sex workers, people who inject drugs, prisoners, transgender people, and gay men and other men who have sex with men—constitute small proportions of the general population, but they are at elevated risk of acquiring HIV infection, in part due to discrimination and social exclusion. A lot of methods to bring patients in care such as APN, SNS, HIVST are used frequently as this has proven to be effective in positive identification thus linkaging patients into care.

In 2018, MARPI also introduced Differentiated Service Delivery Models(DSDMs) guided by the ministry of health (M.O.H) to improve the efficiency of the existing care and treatment approaches by addressing KP/PP needs, informing targeted interventions with better outcomes. These models have greatly improved access, coverage and quality of services leading to efficient utilization of resources.